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Outline
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The Haematological Malignancy Genomics Laboratory operates a comprehensive translational research program in haematological malignancies with focus on multiple myeloma, an incurable B-cell malignancy. In addition, we also study acute myeloid leukaemias harboring FLT3 mutations in relation to their drug resistance mechanism, including epigenetic deregulation. At the core of this program is the use of high-throughput cutting edge genomics and proteomics techniques in both human tumor samples and novel mouse model to make clinically relevant discoveries. These discoveries will encompass novel biological insights, identification of new diagnostic subtypes, prognostic factors, therapeutic targets, and aspects of molecular epidemiology and pharmacogenomics, all with potential impact on patient care. In this bench-to-bedside translational pipeline, discoveries are validated in the pre-clinical setting before clinical validation. The program will be supported by a comprehensive tissue bank that provides high-quality source materials for down-stream study, and a clinical database that is connected by a relational database for integrated system biology analysis (See Figure Below).
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Colloborators
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Clinical
Dr Liu Te Chih (NUH)
Dr Tan Lip Kun (NUH)
Dr Koh Liang Piu (NUH)
Dr Goh Yeow Tee (SGH)
Dr Daryl Tan (SGH)
Dr Kuperan (TTSH)
Dr Ong Kiat Hoe (TTSH)
Dr Allen Yeoh (NUH Paediatrics)
Clinical Trials and Research Group (CTRG – multicenter, multinational)
Pathology
A/Prof Evelyn Koay (Molecular Diagnostic Center, NUH)
Dr Ng Siok Bian (Pathology, NUH)
School of Computing
Prof Wong Limsoon
A/Prof Ken Sung
A/Prof Anthony Tung
Genomic Institute of Singapore, A*STAR
Ruan YJ
Lance Miller
Institute of Molecular and Cell Biology, A*STAR
Prof Neal Copeland
Prof Nancy Jenkins
Mayo Clinic, USA
Prof Rafael Fonseca
A/Prof Leif Bergsagel
Dr Ellen Remstein
Dr Ahmet Dogan
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